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    Rheumatoid Arthritis


What is rheumatoid arthritis?

Rheumatoid arthritis (RA) is a form of arthritis that occurs when the lining of the joints - the synovium - becomes inflamed. This inflammation causes the synovium to thicken. Fluid is produced by the joint lining, which causes swelling and stiffness. Organs other than the joints can also be affected in RA and people with RA often have generalised symptoms such as fatigue, low-grade fever and muscle aches.

RA most commonly affects joints of the fingers and toes, wrists, elbows, shoulders, some joints in the neck, jaw, hips, knees, ankles and feet. The same joints are usually affected on both sides of the body.

What causes RA?

Exactly why certain people develop RA is not known. Researchers currently believe that a person's genetic makeup might make them more susceptible to developing RA.

The symptoms of RA

RA is known as an autoimmune disease. Autoimmune diseases develop when the immune system of the body is stimulated either by genetic or environmental factors, resulting in a dramatic response. The immune system starts to react against certain parts of the body, and in doing so causes the inflammation that is responsible for the symptoms of RA.
The symptoms of RA may be confined to the joints or affect other parts of the body.

Symptoms in the joints

If RA is not treated effectively, persistent inflammation can damage nearby bone, cartilage, tendons and ligaments. The joints may change shape or movement may become very difficult and painful.

Symptoms other than the joints
RA most commonly affects the joints although symptoms in other parts of the body may also occur. These include:

General feelings of fatigue, loss of appetite or fever.

Tiredness and lethargy, which may be due to anaemia (a drop in the number of red cells in the blood).

Rheumatoid nodules. These small lumps underneath the skin are almost always harmless but can cause discomfort if they are in places where they are bumped or rubbed.

Dry eyes and mouth. This happens when the tear and salivary glands become inflamed.

Numbness or weakness in the arms or legs. This occurs when nerves and their surrounding tissues become inflamed.

Chest pains with deep breaths. This is usually due either to inflammation of the lining of the lungs or arthritis in the joints between the collarbones and chest bone.

Ulcers or splinter-like lesions appearing on the skin. These are signs of the rare condition called vasculitis, which occurs when the blood vessels become inflamed. Vasculitis may also affect the internal organs.


Diagnosing rheumatoid arthritis

The symptoms of RA are often very similar to other conditions. Your doctor will ask you about your symptoms - which joints are affected, when you experience pain and how long the pain lasts. You will also be asked questions about your medical history and that of your family.

You will undergo a physical examination, where your doctor will examine your joints and assess your general health. Your doctor will then carry out several laboratory tests to help confirm the diagnosis.


What does the future hold?

RA is an unpredictable disease. In some people, it is mild with periods of increased disease activity called flares. In others, the disease is active all the time and may get progressively worse. About one in 10 people with RA have a single episode of joint inflammation followed by a long-lasting remission where they experience no symptoms.

At present there is not cure for RA but with the appropriate medication the symptoms can be well controlled. There are many things you can do to help yourself. (See Information Sheet: Rheumatoid Arthritis No. 2. Non-drug therapy / lifestyle modifications)

Can people with RA have children?

RA should not prevent you from having a child. You should discuss pregnancy with your doctor before attempting to conceive, as many of the medications used to treat RA are harmful to an unborn child. Men with RA need to consult their doctor if they are considering fathering children as some medications can adversely affect the baby via the father's sperm.

Diet and nutrition

While there is no specific diet that is of proven benefit in RA, you should try to maintain a healthy, low-fat diet Ensure you have enough calcium in your diet, as people with RA, especially women, are at an increased risk of osteoporosis.

Surgery

In some cases, it is beneficial to undergo surgery on severely damaged joints or those that are causing a lot of pain. Doctors who specialise in bone and joint surgery can perform joint replacements.

The information presented is not intended to replace the medical advice of your doctor or health care provider. Arthritis SA recommends that you consult your doctor about specific medical conditions.

Other information and resources available from Arthritis SA

Rheumatoid Arthritis No. 2 Fact Sheet : Non-drug therapy/lifestyle modifications.
Rheumatoid Arthritis No 3 Fact Sheet.: Drug therapy
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Library
Arthritis and Rheumatism by Andrei Calin and John Cormack, 1996
Coping with Rheumatoid Arthritis by Robert Phillips, 1988
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Book Sales
Living a Healthy Life with Chronic Conditions by Kate Lorig, Halsted Holman, David Sobel, Diana Laurent, Virginia Gonzalez and Marian Minor, 2000
Rheumatism, a consumer's guide by Geoffrey Littlejohn, 1989
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Tai Chi for Arthritis 2, by Dr Paul Lam, 2001
Exercise beats arthritis, 1993 (Video only)
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